To explore all-cause mortality risk and its influencing factors in female patients with young-onset type 2 diabetes mellitus (YOD).
Key Findings:
All-cause mortality rate was 21.6% with 1293 deaths recorded during the follow-up, indicating significant mortality risk among this population.
Young-onset diabetes (YOD) patients had a lower mortality rate compared to late-onset diabetes (LOD) patients, highlighting the need for targeted interventions.
Nonyoung menopausal group (NYM) had the highest mortality rate at 24%, while young premenopausal group (YP) had the lowest at 3.7%, suggesting menopause status significantly influences mortality.
TyG-BMI was identified as an independent protective factor for the young menopausal group, with a hazard ratio indicating a 2% decrease in mortality risk for each standard deviation increase.
Interpretation:
Postmenopausal women with YOD face a higher mortality risk compared to premenopausal women with LOD, and higher TyG-BMI levels are associated with reduced mortality risk.
Limitations:
Study limited to a specific geographic area, which may affect generalizability; further research is needed to validate findings in diverse populations.
Potential confounding factors, such as lifestyle and comorbidities, were not fully accounted for in the analysis, which may influence the results.
Conclusion:
Early identification and intervention of TyG-BMI levels in postmenopausal women with YOD may help identify high-risk individuals and guide timely interventions to reduce mortality risk.
