Erythrocyte odd-chain fatty acids and the risk of cardiometabolic diseases: a prospective study and updated meta-analysis - Summary - MDSpire

Erythrocyte odd-chain fatty acids and the risk of cardiometabolic diseases: a prospective study and updated meta-analysis

  • By

  • Liang Sun

  • Xinming Xu

  • Huaidong Du

  • Ling Lu

  • Fumiaki Imamura

  • Qishan Yang

  • Yiping Chen

  • Yan Chen

  • Pei Pei

  • Huiyong Yin

  • Ling Yang

  • Geng Zong

  • Canqing Yu

  • Qianqian Chu

  • Jun Lv

  • Puchen Zhou

  • Dianjianyi Sun

  • Junshi Chen

  • Xiang Gao

  • Liming Li

  • Zhengming Chen

  • Xu Lin

  • on behalf of the China Kadoorie Biobank Collaborative Group

  • September 24, 2025

  • 0 min

Share

Objective:

To determine dietary sources of odd-chain fatty acids (OCFAs) in Asians and their associations with cardiometabolic diseases (CMDs), while comparing these associations with those observed in other populations.

Key Findings:
  • OCFAs were significantly correlated with intakes of dairy products, wheat, coarse grains, and fish/seafood, highlighting their dietary relevance.
  • Both 15:0 and 17:0 were inversely associated with incident IHD, with adjusted HRs of 0.72 and 0.69, respectively, indicating a protective effect.
  • 17:0 was inversely associated with incident diabetes (HR 0.41) and total CMDs (HR 0.85), suggesting its potential as a biomarker.
  • Meta-analysis showed inverse associations of 15:0 and 17:0 with diabetes, with pooled relative risks of 0.74 and 0.65, respectively, reinforcing their significance.
Interpretation:

The study supports favorable associations between OCFAs and CMDs in Asian populations, suggesting that OCFAs may serve as biomarkers for dietary intake and could aid in risk stratification and dietary interventions, particularly in populations with diverse dietary habits.

Limitations:
  • The study primarily focused on a Chinese population, which may limit generalizability to other ethnic groups.
  • Reliance on self-reported dietary intake may introduce measurement errors.
  • Potential confounding factors, such as lifestyle and genetic predispositions, were not fully addressed.
Conclusion:

Erythrocyte levels of 15:0 and 17:0 are associated with a lower risk of IHD and diabetes in Asian populations, indicating their potential as modifiable biomarkers for nutritional assessment and intervention strategies.

Original Source(s)

Erythrocyte odd-chain fatty acids and the risk of cardiometabolic diseases: a prospective study and updated meta-analysis

  • by Liang Sun, Xinming Xu, Huaidong Du, Ling Lu, Fumiaki Imamura, Qishan Yang, Yiping Chen, Yan Chen, Pei Pei, Huiyong Yin, Ling Yang, Geng Zong, Canqing Yu, Qianqian Chu, Jun Lv, Puchen Zhou, Dianjianyi Sun, Junshi Chen, Xiang Gao, Liming Li, Zhengming Chen, Xu Lin, on behalf of the China Kadoorie Biobank Collaborative Group

  • September 24, 2025

Related Content

The association between the C-reactive protein-triglyceride glucose index and myocardial injury after acute ischemic stroke: a machine learning analysis of the brain-heart axis

Triangulating evidence for cardiometabolic Index: ROC cutoff, spline nonlinearity, and explainable machine learning for CVD high risk

Retatrutide Shows 28% Weight Loss in Phase 3 Trial

Nearly half of participants receiving the highest dose achieved at least 30% body weight reduction.