Objective:

To investigate whether electroacupuncture (EA) attenuates eosinophilic inflammation in allergic rhinitis (AR) and to explore the underlying neuroimmune mechanisms.

Approach:

Key Findings:

• EA reduced nasal rubbing, redness, and olfactory dysfunction, comparable to CLP.
• Both EA and CLP reduced IL-5, IL-13, and serum OVA-specific IgE levels.
• Only EA reversed OVA-induced nasal eosinophil infiltration and suppressed RNASE2A expression.
• Pre-treatment with β2-adrenergic antagonist butoxamine abolished EA's effects on eosinophilic inflammation.
• EA was associated with elevated plasma norepinephrine and epinephrine levels.

Interpretation:

EA reduces eosinophilic inflammation and AR behaviors through β2-adrenergic receptor activation, differing from standard antihistamines that primarily target mast cells.

Conclusion:

EA represents a promising complementary intervention for eosinophil-driven allergic rhinitis.

Attribution Notice

This content is an AI-generated, fully rewritten summary based on a published scholarly article. It does not reproduce the original text and is not a substitute for the original publication. Readers are encouraged to consult the source for full context, data, and methodology.