Cognitive-motor network integration as a behavioral marker of cognitive reserve in post-stroke rehabilitation - Summary - MDSpire

Cognitive-motor network integration as a behavioral marker of cognitive reserve in post-stroke rehabilitation

  • By

  • Katharina Kreiger

  • Elisabeth Weiss

  • Felix Fluri

  • June 9, 2026

  • 0 min

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Objective:

To investigate the predictive value of traditional cognitive reserve proxies on rehabilitation response and differences in baseline cognitive performance structure between responders and non-responders.

Key Findings:
  • Cognitive leisure activities were the strongest predictor of responder status (OR = 4.84).
  • Exploratory factor analysis revealed two cognitive dimensions: Memory and Executive-Spatial.
  • Responders did not show significantly higher baseline cognitive scores compared to non-responders, indicating no clear advantage in initial cognitive performance.
  • Network analyses indicated a more integrated cognitive-motor architecture in responders, characterized by higher density and lower sparsity.
Interpretation:

Remove this section or rephrase to avoid unsupported conclusions.

Limitations:
  • The study is retrospective and may be subject to selection bias.
  • Findings may not be generalizable beyond the studied population.
Conclusion:

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