To review the evolution of psychosurgery and its contemporary applications in treating severe psychiatric disorders through a circuit-based approach, which focuses on the neural networks involved in these conditions.
Key Findings:
Contemporary psychosurgery is shifting towards a network-based, multimodal intervention model, with a focus on specific brain networks.
Modern techniques include both ablative and stimulation-based approaches, targeting specific brain networks, which are informed by connectomic insights.
Interpretation:
Psychosurgery is evolving into a precision psychiatry model. This model focuses on symptom dimensions and connectomic-guided targeting, moving away from traditional diagnostic categories.
Limitations:
The review is not a formal systematic review and relies on non-systematic searches, which may introduce bias.
Heterogeneity in study designs may affect the strength of evidence presented, particularly in terms of outcome measures and patient populations.
Conclusion:
Contemporary psychosurgery should be viewed as a nuanced, network-based intervention for carefully selected patients with treatment-refractory psychiatric disorders.
by Victor González, Jordi Rumià, Marta Brell, Carolina Roset, José de Miguel, Susana Arboleya, Iratxe Aguirre, Daniel Alegre, Victor Goliney, Javier Ibáñez
