A Web-Based Intervention for Reducing Sexually Transmitted Infections and Substance Use During Pregnancy: Randomized Controlled Trial - Summary - MDSpire

A Web-Based Intervention for Reducing Sexually Transmitted Infections and Substance Use During Pregnancy: Randomized Controlled Trial

  • By

  • Golfo Tzilos Wernette

  • Ananda Sen

  • Dongru Chen

  • Kristina Countryman

  • Okeoma Mmeje

  • Quyen M Ngo

  • Katherine J Gold

  • Christopher W Kahler

  • Caron Zlotnick

  • July 8, 2026

  • 0 min

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Objective:

To test whether the Health Check-Up for Expectant Moms (HCEM) reduces condomless sex or STI risk, alcohol or drug use, compared to a control condition in a larger, more diverse sample of pregnant women seeking prenatal care.

Approach:
  • Participant Recruitment: Participants were recruited in-person and remotely, with initial recruitment from April 2019 to March 2020 and remote recruitment from August 2020 to September 2023.
  • Intervention Description: The HCEM is a technology-delivered brief intervention consisting of a single session plus two booster sessions aimed at reducing alcohol or drug use and STI risk during pregnancy.
Key Findings:
  • The HCEM was associated with a significantly larger reduction in cannabis or alcohol use during pregnancy compared to the control group, with specific statistical significance levels reported.
  • High ratings of acceptability were noted in the pilot randomized controlled trial with a sample of 50 pregnant women.
Interpretation:

The study suggests that technology-delivered interventions like HCEM may effectively reduce substance use and STI risk among pregnant women.

Limitations:
  • The study's recruitment was affected by the SARS-CoV-2 pandemic, which may limit generalizability.
  • Participants required internet access and device literacy, potentially excluding some populations.
Conclusion:

The HCEM intervention shows potential in addressing substance use and STI risk in pregnant women.

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