Objective:

To analyze the outcomes of 12-month naturalistic treatment with cariprazine and elucidate changes in specific psychopathological domains between men and women.

Approach:

Key Findings:

• Both genders showed improvements in all PANSS subscale symptoms after 6 and 12 months of treatment, except for uncontrolled hostility/excitement in men.
• Gender-specific response profiles emerged in PANSS subscales and items after 6 and 12 months of treatment.
• Mean dose of cariprazine was 4.2 mg for men and 4.0 mg for women.

Interpretation:

Cariprazine demonstrated significant efficacy in both sexes, with no significant differences in overall treatment outcomes.

Limitations:

• Small sample size with only 32 subjects.
• Further studies needed to explore long-term outcomes and efficacy profiles by gender.

Conclusion:

The study highlights the importance of considering gender in treatment response profiles for schizophrenia.

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