Glucagon-stimulated copeptin response In Children: A Proof-Of-Concept Study - Summary - MDSpire

Glucagon-stimulated copeptin response In Children: A Proof-Of-Concept Study

  • By

  • Indirli, Rita

  • Giacchetti, Federico

  • Profka, Eriselda

  • Rodari, Giulia

  • Petria, Iulia

  • Arosio, Maura

  • Giavoli, Claudia

  • Mantovani, Giovanna

  • Ferrante, Emanuele

  • May 27, 2026

  • 0 min

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Objective:

To investigate copeptin response to glucagon stimulation test (GST) in children tested for suspected growth hormone (GH) deficiency.

Approach:
    Key Findings:
    • Median copeptin concentration was 4.1 pmol/L at baseline and peaked at 10.6 pmol/L (+87% at 150 minutes).
    • No adverse events were recorded during the study.
    Interpretation:

    Limitations:
    • The study is preliminary and involves a small sample size.
    • Further studies are needed to assess the accuracy of GST in the differential diagnosis of PPS.
    Conclusion:

    Further studies are warranted to assess GST's accuracy in diagnosing PPS.

Original Source(s)

Glucagon-stimulated copeptin response In Children: A Proof-Of-Concept Study

  • by Indirli, Rita , Giacchetti, Federico , Profka, Eriselda , Rodari, Giulia , Petria, Iulia , Arosio, Maura , Giavoli, Claudia , Mantovani, Giovanna , Ferrante, Emanuele

  • May 27, 2026

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