Objective:

To evaluate urinary function, quality of life, sexual function, fatigue, and psychological well-being in women treated for cervical cancer, with particular emphasis on treatment modality and the integration of urodynamic findings with patient-reported outcomes.

Approach:

• Study Design: Multicenter observational study including 132 women treated for cervical cancer, with assessments before treatment and follow-ups at 3, 6, and 9 months post-treatment.
• Assessment Methods: Urodynamic testing and patient-reported outcomes using validated questionnaires (IIQ-7, UDI-6, SWLS, FACIT-F, HADS, FSFI).

Key Findings:

• Urinary dysfunction was common and worsened over time, particularly in women receiving radiotherapy.
• Objective findings indicated reduced bladder capacity and increased prevalence of detrusor overactivity in patients treated with radiotherapy.
• Pain intensity, fatigue, anxiety, and depressive symptoms increased, while life satisfaction and sexual function declined, especially in patients receiving combined treatment.
• Weak correlations were found between urodynamic findings and patient-reported outcomes.

Interpretation:

Cervical cancer treatment, particularly radiotherapy, is associated with persistent urinary dysfunction and declines in quality of life, fatigue, psychological well-being, and sexual function.

Limitations:

• Limited sample size and potential selection bias.
• Lack of long-term follow-up data beyond 9 months.

Conclusion:

Combining urodynamic assessments with patient-reported outcomes provides a comprehensive evaluation of treatment-related morbidity.