Effect of a ketogenic diet, time-restricted eating, or alternate-day fasting on changes in ambulatory blood pressure: a sub-analysis of a randomized clinical trial - Summary - MDSpire
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Effect of a ketogenic diet, time-restricted eating, or alternate-day fasting on changes in ambulatory blood pressure: a sub-analysis of a randomized clinical trial
To assess changes in blood pressure through 24-h ambulatory blood pressure monitoring (ABPM) in different hypocaloric diets differing in their theoretical ketogenic potential, particularly in the context of obesity management.
Key Findings:
All groups showed statistically significant changes in anthropometric parameters, with mADF exhibiting the greatest improvements in ABPM parameters post-intervention.
lTRE showed some improvements, while other groups did not demonstrate significant changes.
mADF influenced the reduction in 24-h systolic blood pressure, highlighting its effectiveness.
Changes in body fat were linked to reductions in blood pressure, suggesting a potential mechanism.
Interpretation:
Different hypocaloric diets have varying effectiveness in reducing blood pressure, with modified alternate-day fasting being the most effective approach, which may inform dietary recommendations for obesity management.
Limitations:
Single-centre study may limit generalizability to broader populations.
Sample size of 96 participants may not capture the effects across diverse demographics.
Conclusion:
Low-calorie diets with varying ketogenic potentials can effectively reduce blood pressure in obese individuals, with mADF being the most beneficial approach.
by Ana María Gómez-Pérez, Borja Bandera-Merchán, José Ignacio Martínez-Montoro, Mario Gutiérrez-Bedmar, Cristina Díaz-Perdigones, Alba Subiri-Verdugo, Isabel Moreno-Indias, Francisco J Tinahones
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