Comparability of Gastrointestinal Microbiome and Bile Acid Profiles in Patients With First or Multiply Recurrent Clostridioides difficile Infection - Summary - MDSpire

Comparability of Gastrointestinal Microbiome and Bile Acid Profiles in Patients With First or Multiply Recurrent Clostridioides difficile Infection

  • By

  • Jessica A Bryant

  • Timothy J Straub

  • Darrell S Pardi

  • Kevin D Litcofsky

  • Colleen R Kelly

  • Meghan E Chafee

  • Stuart H Cohen

  • Sahil Khanna

  • Charles S Berenson

  • Jennifer Wortman

  • Matthew Sims

  • Christopher B Ford

  • Mary-Jane Lombardo

  • Barbara H McGovern

  • Lisa von Moltke

  • Colleen S Kraft

  • Matthew R Henn

  • Brooke R Hasson

  • August 2, 2025

  • 0 min

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Objective:

To compare gastrointestinal microbiome and bile acid profiles between patients with first Clostridioides difficile infection (frCDI) and multiply recurrent CDI (mrCDI) to inform treatment strategies specifically for recurrent CDI (rCDI).

Key Findings:
  • rCDI rates were low in both frCDI (6.5%) and mrCDI (9.7%) patients after VOS treatment, indicating effective management.
  • Baseline microbial diversity was low and similar between frCDI and mrCDI groups, suggesting common microbiome disruptions.
  • Diversity and secondary bile acid concentrations increased, while primary bile acid concentrations decreased after VOS dosing, highlighting the treatment's impact.
Interpretation:

The findings suggest that both frCDI and mrCDI share common microbiome disruptions, indicating that antibiotics followed by live microbiome therapy may be effective for rCDI management, regardless of prior recurrence history, thus informing future treatment strategies.

Limitations:
  • The study is a post hoc analysis, which may limit the robustness of conclusions drawn from the data.
  • Sample size and demographic diversity were not detailed, potentially affecting the generalizability of the findings.
Conclusion:

Antibiotic treatment followed by live microbiome therapy may optimize rCDI management, underscoring the need for further exploration of microbiome restoration strategies in CDI treatment.

Original Source(s)

Comparability of Gastrointestinal Microbiome and Bile Acid Profiles in Patients With First or Multiply Recurrent Clostridioides difficile Infection

  • by Jessica A Bryant, Timothy J Straub, Darrell S Pardi, Kevin D Litcofsky, Colleen R Kelly, Meghan E Chafee, Stuart H Cohen, Sahil Khanna, Charles S Berenson, Jennifer Wortman, Matthew Sims, Christopher B Ford, Mary-Jane Lombardo, Barbara H McGovern, Lisa von Moltke, Colleen S Kraft, Matthew R Henn, Brooke R Hasson

  • August 2, 2025

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