Objective:

To report cases of anaphylactic shock following fecal microbiota transplantation (FMT) in children with autism spectrum disorder (ASD) and multiple food intolerances (FI).

Approach:

Key Findings:

• Both children experienced anaphylactic shock after FMT, marking the first report of such events in pediatric patients.
• Case 1 had early-stage shock linked to IgG-mediated type III hypersensitivity.
• Case 2 exhibited classic anaphylactic shock with a biphasic course.
• Both children improved with anti-allergy and anti-shock treatment, and one successfully underwent subsequent FMT.

Interpretation:

Limitations:

• The cases are limited to two patients, which may not represent the broader population.
• Lack of established clinical strategies for risk prevention and management in this high-risk subgroup.

Conclusion:

Attribution Notice

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