Combined Immunity from Infection and Vaccination Against Confirmed SARS-CoV-2 Infections in a European Multi-Center Prospective Study of Healthcare Workers, 2021–2024 - Summary - MDSpire

Combined Immunity from Infection and Vaccination Against Confirmed SARS-CoV-2 Infections in a European Multi-Center Prospective Study of Healthcare Workers, 2021–2024

  • By

  • Madelyn Rojas-Castro

  • Ranya Mulchandani

  • Kim Brolin

  • Zvjezdana Lovrić Makarić

  • Anneli Uusküla

  • Colm Bergin

  • Catherine Fleming

  • Paolo Bonfanti

  • Rita Murri

  • Viesturs Zvirbulis

  • Dace Zavadska

  • Konstanty Szuldrzynski

  • Vânia Gaio

  • Corneliu Petru Popescu

  • Mihai Craiu

  • Raluca-Maria Hrișcă

  • Maria Cisneros

  • Miriam Latorre-Millán

  • Goranka Petrović

  • Liss Lohur

  • Jonathan McGrath

  • Lauren Ferguson

  • Anna Spolti

  • Katleen De Gaetano Donati

  • Ilze Abolina

  • Dagne Gravele

  • Ausenda Machado

  • Simin Aysel Florescu

  • Mihaela Lazar

  • Pilar Subirats

  • Laura Clusa

  • Gordan Sarajlić

  • Jacklyn Sui

  • Claire Kenny

  • Rosaria Santangelo

  • Dainis Krievins

  • Elza Anna Barzdina

  • Camila Valadas Henriques

  • Alma Gabriela Kosa

  • Săftica-Mariana Pohrib

  • Victor Daniel Miron

  • Carmen Muñoz-Almagro

  • Ana Maria Milagro

  • Sabrina Bacci

  • Camelia Savulescu

  • December 29, 2025

  • 0 min

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Objective:

To measure the effect of hybrid, infection, or vaccine-induced immunity against SARS-CoV-2 infection among healthcare workers during the circulation of various Omicron sub-lineages, specifically BA.1/2, BA.4/5/BQ.1, BA.2/XBB, and XBB.1.5/BA.2.86.

Key Findings:
  • Hybrid immunity provides robust protection against SARS-CoV-2 infections.
  • Healthcare workers showed varying levels of immunity based on vaccination and prior infection status, with implications for tailored vaccination strategies.
  • The study highlights the importance of ongoing vaccination strategies in high-risk groups, emphasizing the need for continuous adaptation to emerging variants.
Interpretation:

The findings underscore the significance of hybrid immunity in protecting healthcare workers against SARS-CoV-2, particularly during the emergence of new variants.

Limitations:
  • Limited real-world evidence on hybrid immunity in the post-pandemic era, particularly among immunocompromised individuals.
  • Exclusion of immunocompromised individuals and those with inconsistent serologic results may affect generalizability, limiting applicability to broader populations.
Conclusion:

Understanding the dynamics of hybrid immunity is crucial for informing future COVID-19 vaccination policies, especially for healthcare workers, and for developing strategies applicable to the general population.

Original Source(s)

Combined Immunity from Infection and Vaccination Against Confirmed SARS-CoV-2 Infections in a European Multi-Center Prospective Study of Healthcare Workers, 2021–2024

  • by Madelyn Rojas-Castro, Ranya Mulchandani, Kim Brolin, Zvjezdana Lovrić Makarić, Anneli Uusküla, Colm Bergin, Catherine Fleming, Paolo Bonfanti, Rita Murri, Viesturs Zvirbulis, Dace Zavadska, Konstanty Szuldrzynski, Vânia Gaio, Corneliu Petru Popescu, Mihai Craiu, Raluca-Maria Hrișcă, Maria Cisneros, Miriam Latorre-Millán, Goranka Petrović, Liss Lohur, Jonathan McGrath, Lauren Ferguson, Anna Spolti, Katleen De Gaetano Donati, Ilze Abolina, Dagne Gravele, Ausenda Machado, Simin Aysel Florescu, Mihaela Lazar, Pilar Subirats, Laura Clusa, Gordan Sarajlić, Jacklyn Sui, Claire Kenny, Rosaria Santangelo, Dainis Krievins, Elza Anna Barzdina, Camila Valadas Henriques, Alma Gabriela Kosa, Săftica-Mariana Pohrib, Victor Daniel Miron, Carmen Muñoz-Almagro, Ana Maria Milagro, Sabrina Bacci, Camelia Savulescu

  • December 29, 2025

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