Trends and variation in use of end-tidal carbon dioxide during in-hospital cardiac arrest: an observational cohort study - Summary - MDSpire

Trends and variation in use of end-tidal carbon dioxide during in-hospital cardiac arrest: an observational cohort study

  • By

  • Luke Andrea

  • Joshua M Kimbrell

  • Shilpa Kolli

  • Michelle M Nassal

  • Ari Moskowitz

  • June 18, 2026

  • 0 min

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Objective:

To characterize trends and hospital-level variation in end-tidal carbon dioxide (EtCO2) use for airway confirmation and monitoring during in-hospital cardiac arrest, focusing on specific applications and outcomes.

Key Findings:
  • 92.6% of in-hospital cardiac arrests with a new airway were confirmed with EtCO2 from 2019 to 2023, indicating high adherence to guidelines.
  • 35.3% of in-hospital cardiac arrests with either a new or prior airway had EtCO2 applied for CPR monitoring during the same period, suggesting a need for improvement.
  • Little variation in hospital proportions for airway confirmation (median 94.0%), but high variation for CPR monitoring, indicating inconsistent practice.
Interpretation:

EtCO2 application is widely used for confirming airway placement during in-hospital cardiac arrest, but adherence to guidelines for CPR monitoring is inconsistent, which may impact patient outcomes.

Limitations:
  • The study is observational and descriptive, lacking prespecified hypotheses or comparative analyses, which may limit causal inferences.
  • Missing documentation of EtCO2 use for CPR monitoring was treated as non-use, potentially underestimating actual use and affecting the reliability of the findings.
Conclusion:

While EtCO2 is commonly used for airway confirmation, there are significant gaps in its use for CPR monitoring in accordance with guidelines, highlighting the need for improved adherence.

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