Severe-extensive coronary atherosclerosis in low-risk individuals and absence of coronary atherosclerosis in high-risk individuals: the SCAPIS extremes project - Summary - MDSpire
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Severe-extensive coronary atherosclerosis in low-risk individuals and absence of coronary atherosclerosis in high-risk individuals: the SCAPIS extremes project
To assess the presence and absence of coronary atherosclerosis in individuals at high and low estimated cardiovascular risk, highlighting the unexpected outcomes.
Key Findings:
1.2% of non-diabetic subjects and 14.0% of diabetic subjects exhibited no coronary plaques despite being classified as high SCORE2 risk.
0.7% of non-diabetic subjects and 0.3% of diabetic subjects showed severe-extensive coronary plaques despite being classified as low SCORE2 risk.
Factors associated with severe-extensive coronary plaque burden included male gender, older age, smoking history, hypertension, and hyperlipidaemia.
Interpretation:
The study highlights a significant mismatch between estimated cardiovascular risk and actual coronary atherosclerosis, indicating the need for improved risk assessment methods to better identify individuals at risk.
Limitations:
The study is cross-sectional, limiting causal inferences regarding the relationship between risk factors and coronary atherosclerosis.
Findings may not be generalizable beyond the Swedish population, which may have unique demographic and health characteristics.
Conclusion:
Future research is needed to explore protective mechanisms against atherosclerosis in high-risk individuals and to refine cardiovascular risk assessment tools, particularly in identifying those who may be misclassified.
by Madeleine Johansson, Göran Bergström, Tomas Jernberg, Emil Hagström, Stefan Söderberg, Carl Johan Östgren, Gunnar Engström, Anders Gottsäter, Peter M Nilsson
Federal prosecutors allege that a Florida physician and research staff fabricated clinical trial records that were submitted into database systems used to evaluate investigational drugs.
