To evaluate the association between hidradenitis suppurativa (HS) and cancer risk compared to the general population, focusing on specific cancer types.
Key Findings:
Patients with HS had 1.82 times the odds of developing cancer compared to the general population (unadjusted).
Elevated risks were observed for head and neck cancers (2.41 times), respiratory cancers (1.81 times), hematologic malignancies (1.71 times), and gastrointestinal cancer (1.61 times).
Increased odds for Hodgkin lymphoma (2.44 times) and non-Hodgkin lymphoma (1.15 times) were noted (unadjusted).
Certain cancers, including bone, soft-tissue, breast, CNS, urogenital, and unspecified cancers, showed no increased risk.
Interpretation:
The findings suggest a multifactorial relationship between HS and cancer risk, potentially influenced by inflammation, comorbid conditions, and other factors.
Limitations:
Limited adjustments for confounders such as smoking, obesity, and alcohol use.
Inconsistent reporting of key variables like body mass index and ethnicity.
Incomplete reporting of cancer subtypes and disease severity.
Conclusion:
Having HS is associated with an increased risk of cancer overall, including specific subtypes, compared to controls.
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