Body mass index is not a predictor of biochemical recurrence after radical prostatectomy in Dutch men diagnosed with prostate cancer - Summary - MDSpire
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Body mass index is not a predictor of biochemical recurrence after radical prostatectomy in Dutch men diagnosed with prostate cancer
To determine the effects of BMI on specific clinical and pathological findings at diagnosis and the risk of biochemical recurrence (BCR) after radical prostatectomy (RP) among Dutch men with prostate cancer.
Key Findings:
No significant differences in clinical or pathological findings among BMI groups (P > 0.05).
Obese patients had a higher prediagnostic PSA level (P = 0.004) and a higher tumor stage (P = 0.017) compared to other groups.
The 5-year risk of BCR was similar across BMI categories: 30% (normal weight), 32% (overweight), and 25% (obese), with no significant log-rank difference (P = 0.810).
BMI was not a significant prognostic factor for BCR in both univariable (HR 1.02, 95% CI) and multivariable analyses (HR 0.99, 95% CI).
Interpretation:
The study suggests that BMI does not significantly influence the risk of biochemical recurrence after radical prostatectomy in Dutch men with prostate cancer, contradicting some previous findings, particularly in the context of studies conducted in the U.S.
Limitations:
The study is limited to a specific population (Dutch men) and may not be generalizable to other populations, particularly those with different obesity prevalence.
Self-reported BMI data may introduce bias, potentially affecting the accuracy of the findings.
Conclusion:
BMI is not a reliable predictor of biochemical recurrence after radical prostatectomy in the studied cohort, highlighting the need for further research on obesity's role in prostate cancer outcomes, particularly in diverse populations.
by Dieuwertje E. G. Kok, Joep G. H. van Roermund, Katja K. Aben, Moniek W. M. van de Luijtgaarden, Herbert F. M. Karthaus, Oncko B. van Vierssen Trip, Ellen Kampman, J. Alfred Witjes, Lambertus A. L. M. Kiemeney
