Case Report: Pediatric nasopharyngeal carcinoma masquerading as benign lymphadenopathy: diagnostic pitfalls in two cases
By
Yuhan Qiu
Yan Cheng
Aiqin Lin
Hui Li
Jie Liu
Wei Zhang
June 16, 2026
Objective: To highlight the diagnostic challenges of pediatric nasopharyngeal carcinoma (NPC) that can mimic benign lymphoproliferative disorders.
Approach: Key Findings: NPC is rare in children, accounting for <1% of pediatric malignancies. Both cases were initially misdiagnosed due to the tumor's mimicry of benign conditions. Interpretation: The rarity of pediatric NPC and its histologic similarities to benign disorders complicate timely diagnosis.
Limitations: The study is based on only two case reports, limiting generalizability. Diagnostic challenges may vary based on clinical settings and available resources. Conclusion: Early recognition and appropriate diagnostic measures are crucial for the timely treatment of pediatric NPC.