Case Report: Pediatric nasopharyngeal carcinoma masquerading as benign lymphadenopathy: diagnostic pitfalls in two cases - Summary - MDSpire

Case Report: Pediatric nasopharyngeal carcinoma masquerading as benign lymphadenopathy: diagnostic pitfalls in two cases

  • By

  • Yuhan Qiu

  • Yan Cheng

  • Aiqin Lin

  • Hui Li

  • Jie Liu

  • Wei Zhang

  • June 16, 2026

  • 0 min

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Objective:

To highlight the diagnostic challenges of pediatric nasopharyngeal carcinoma (NPC) that can mimic benign lymphoproliferative disorders.

Approach:
    Key Findings:
    • NPC is rare in children, accounting for <1% of pediatric malignancies.
    • Both cases were initially misdiagnosed due to the tumor's mimicry of benign conditions.
    Interpretation:

    The rarity of pediatric NPC and its histologic similarities to benign disorders complicate timely diagnosis.

    Limitations:
    • The study is based on only two case reports, limiting generalizability.
    • Diagnostic challenges may vary based on clinical settings and available resources.
    Conclusion:

    Early recognition and appropriate diagnostic measures are crucial for the timely treatment of pediatric NPC.

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