Untargeted or Non-Targeted Screening? - Summary - MDSpire

Untargeted or Non-Targeted Screening?

  • June 19, 2026

  • 6 min

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Objective:

To explore the distinctions between untargeted and non-targeted screening in metabolomics and other fields.

Approach:
    Key Findings:
    • Experts noted a cultural difference in the use of 'untargeted' and 'non-targeted' screening.
    • Fully untargeted screening is characterized by a lack of knowledge about what is being searched for or found, while non-targeted screening involves pre-selected components.
    • Confusion in terminology arises from different methodologies in metabolomics and environmental analysis.
    • Panelists highlighted the absence of a clear distinction between suspect screening, non-targeted screening, and untargeted screening.
    Interpretation:

    The discussion emphasizes the importance of clear terminology to facilitate effective communication among professionals across different fields.

    Limitations:
    • Definitions of untargeted and non-targeted screening vary significantly among experts.
    • The discussion may not reach a consensus due to the diverse perspectives of the panelists.
    Conclusion:

    Recognizing the varying interpretations of these terms is crucial for improving communication and collaboration among researchers.

    Sources:

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