To investigate the impact of varying metabolic, behavioral, and sociodemographic characteristics on mortality rates in individuals with MASLD and MetALD.
Approach:
Key Findings:
Both MASLD and MetALD were associated with increased all-cause mortality compared to controls, with MetALD showing a higher hazard ratio (HR 2.085; 95% CI, 1.127–3.860; p = 0.019).
Cancer-related mortality was significantly higher in both MASLD (HR 2.610; 95% CI, 1.029–6.618; p = 0.043) and MetALD (HR 3.355; 95% CI, 1.097–10.263; p = 0.034).
Excessive alcohol intake and current smoking were independent predictors of mortality in the MetALD group.
In MASLD, being female and having a higher income correlated with lower mortality rates.
Each additional CMRF was linked to increased cardiovascular mortality in MASLD (HR 1.838; 95% CI, 1.320–2.558; p < 0.001).
Interpretation:
The study presents distinct mortality risk profiles for MASLD and MetALD, highlighting the significance of alcohol-related behaviors in MetALD and the influence of metabolic and sociodemographic factors in MASLD.
Limitations:
The study population was limited to individuals aged 20-79 years.
Data was retrospective and reliant on self-reported measures for alcohol consumption and lifestyle factors.
Conclusion:
Both MASLD and MetALD are linked to increased mortality, but the risk factors differ between the two conditions.
