To evaluate the efficacy of pre-TRUS-PB disinfection with povidone-iodine (PI) plus antibiotic prophylaxis (AP) compared to AP monotherapy in reducing infectious complications, particularly focusing on sepsis outcomes.
Key Findings:
PI disinfection significantly reduced the incidence of infectious complications compared to no disinfection (p < 0.05).
The combination of PI and AP showed a trend towards lower rates of sepsis compared to AP alone, though results were not statistically significant (p > 0.05).
Subgroup analyses indicated variations in efficacy based on the type of antibiotic used, warranting further investigation.
Interpretation:
Povidone-iodine rectal disinfection prior to TRUS-PB may be beneficial in reducing infectious complications, particularly fever, but its impact on sepsis requires further investigation to clarify its clinical significance.
Limitations:
Variability in definitions of fever and sepsis across studies may affect the comparability of results.
Limited number of studies specifically addressing sepsis outcomes highlights the need for more focused research.
Potential biases in included studies, despite quality assessments, may influence the reliability of findings.
Conclusion:
Povidone-iodine disinfection prior to TRUS-PB is recommended to mitigate infection risks, but further research is needed to clarify its role in preventing sepsis and to strengthen clinical guidelines.
