Association between anxiety disorders and medication adherence in patients with cardiovascular disease: a systematic review and meta-analysis of observational studies - Summary - MDSpire

Association between anxiety disorders and medication adherence in patients with cardiovascular disease: a systematic review and meta-analysis of observational studies

  • By

  • Tingting Wang

  • Zhiyong Li

  • Yunjie Wei

  • Xiaofei Zhang

  • Qianjiao Yuan

  • Xiaohong Zhang

  • Xuying Li

  • Qinqin Lei

  • October 21, 2025

  • 0 min

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Objective:

To evaluate the association between anxiety disorders and medication adherence in adults with cardiovascular disease, and to investigate variations across subgroups defined by type of CV disease, assessment tools, geographic regions, and demographic factors.

Key Findings:
  • Anxiety disorders are prevalent among cardiovascular disease patients and negatively impact medication adherence.
  • Poor medication adherence is linked to increased morbidity and mortality in cardiovascular disease patients.
  • Existing literature primarily focuses on depression, highlighting a gap in research regarding anxiety disorders.
Interpretation:

The presence of anxiety disorders in cardiovascular patients may significantly hinder their ability to adhere to medication regimens, potentially exacerbating health outcomes such as increased morbidity and mortality.

Limitations:
  • The protocol for the systematic review was not registered in a prospective registry, which may limit transparency.
  • The study selection process may have biases due to the non-mandatory comparator group, potentially affecting the validity of the findings.
Conclusion:

This systematic review and meta-analysis aims to fill the gap in literature regarding the impact of anxiety on medication adherence in cardiovascular disease patients, emphasizing the need for targeted interventions that address both anxiety and cardiovascular health.

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