Intracranial angiomatoid fibrous histiocytoma in a 2-month-old infant: a rare case report - Summary - MDSpire

Intracranial angiomatoid fibrous histiocytoma in a 2-month-old infant: a rare case report

  • By

  • Xiaoyu Yang

  • Xiaofeng Chen

  • Yi Zhang

  • Yanming Ren

  • Junwen Guan

  • Ke Wu

  • June 15, 2026

  • 0 min

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Objective:

To detail the diagnosis and management of angiomatoid fibrous histiocytoma (AFH) in a 2-month-old infant with an intracranial lesion, emphasizing its rarity and clinical challenges.

Approach:
    Key Findings:
    • Intracranial AFH is exceedingly rare in infants, with limited documented cases.
    • Complete surgical resection is the gold-standard management, though outcomes may vary based on surgical experience.
    • Histopathological diagnosis requires immunohistochemistry and molecular genetic testing to confirm AFH.
    Interpretation:

    The case highlights the challenges in diagnosing and managing intracranial AFH in very young infants.

    Limitations:
    • Limited experience in treating very young infants with intracranial tumors may affect treatment outcomes.
    • Need for meticulous intraoperative hemostasis and collaboration with pathologists to ensure accurate diagnosis and management.
    Conclusion:

    Intracranial AFH in infants necessitates careful diagnosis and management strategies, underscoring the importance of early intervention and multidisciplinary collaboration.

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