Prognostic nutritional index, but not NLR or PLR, is linked to survival in multiple myeloma
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By
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Nermin Keni Begendi
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Mustafa Duran
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Yaşar Culha
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May 28, 2026
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Objective:
To evaluate the prognostic significance of PNI, NLR, and PLR in predicting overall survival (OS) in newly diagnosed MM patients.
Key Findings:
- Low PNI (≤34.7) was found in 39.2% of patients and was associated with higher mortality (76.3% vs. 50%, p = 0.02).
- Median OS was significantly shorter in the low PNI group (13.5 months) compared to the high PNI group (53.3 months, p = 0.007).
- No significant differences in median OS were observed between low and high PLR or NLR groups.
- High beta-2 microglobulin (β2M) levels were associated with a 3.19-fold increased risk of death (p = 0.048).
Interpretation:
Remove unsupported conclusions and keep it factual.
Limitations:
- Retrospective design may introduce bias.
- Limited sample size may affect generalizability.
- Exclusion of patients with active infections or other malignancies may limit findings.
Conclusion:
Rephrase to avoid unsupported claims about prognostic significance.