Prognostic nutritional index, but not NLR or PLR, is linked to survival in multiple myeloma
By
Nermin Keni Begendi
Mustafa Duran
Yaşar Culha
May 28, 2026
Objective: To evaluate the prognostic significance of PNI, NLR, and PLR in predicting overall survival (OS) in newly diagnosed MM patients.
Key Findings: Low PNI (≤34.7) was found in 39.2% of patients and was associated with higher mortality (76.3% vs. 50%, p = 0.02). Median OS was significantly shorter in the low PNI group (13.5 months) compared to the high PNI group (53.3 months, p = 0.007). No significant differences in median OS were observed between low and high PLR or NLR groups. High beta-2 microglobulin (β2M) levels were associated with a 3.19-fold increased risk of death (p = 0.048). Interpretation: Remove unsupported conclusions and keep it factual.
Limitations: Retrospective design may introduce bias. Limited sample size may affect generalizability. Exclusion of patients with active infections or other malignancies may limit findings. Conclusion: Rephrase to avoid unsupported claims about prognostic significance.
