Prognostic nutritional index, but not NLR or PLR, is linked to survival in multiple myeloma - Summary - MDSpire

Prognostic nutritional index, but not NLR or PLR, is linked to survival in multiple myeloma

  • By

  • Nermin Keni Begendi

  • Mustafa Duran

  • Yaşar Culha

  • May 28, 2026

  • 0 min

Share

Objective:

To evaluate the prognostic significance of PNI, NLR, and PLR in predicting overall survival (OS) in newly diagnosed MM patients.

Key Findings:
  • Low PNI (≤34.7) was found in 39.2% of patients and was associated with higher mortality (76.3% vs. 50%, p = 0.02).
  • Median OS was significantly shorter in the low PNI group (13.5 months) compared to the high PNI group (53.3 months, p = 0.007).
  • No significant differences in median OS were observed between low and high PLR or NLR groups.
  • High beta-2 microglobulin (β2M) levels were associated with a 3.19-fold increased risk of death (p = 0.048).
Interpretation:

Remove unsupported conclusions and keep it factual.

Limitations:
  • Retrospective design may introduce bias.
  • Limited sample size may affect generalizability.
  • Exclusion of patients with active infections or other malignancies may limit findings.
Conclusion:

Rephrase to avoid unsupported claims about prognostic significance.

Original Source(s)

Related Content