Association of a data-driven nutrient risk score with incident rheumatoid arthritis in UK Biobank adults: a prospective cohort study - Summary - MDSpire
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Association of a data-driven nutrient risk score with incident rheumatoid arthritis in UK Biobank adults: a prospective cohort study
To explore the association between the nutrient risk score (NRS) and incident rheumatoid arthritis (RA), and to assess the modifying effect of genetic susceptibility and the mediating role of obesity.
Key Findings:
During a median follow-up of 13.4 years, 1,756 participants developed RA.
Each unit increase in NRS was associated with a 96% higher risk of RA (HR: 1.96, 95% CI: 1.64-2.33).
The association remained robust in analyses using GPS and IPW weighting.
Stratified analyses indicated a stronger association among individuals with short sleep duration (<7 hours) and low physical activity.
Individuals at high genetic risk with the highest NRS had nearly a twofold higher risk of incident RA (HR: 3.28, 95% CI: 2.49-4.32).
Obesity indicators showed potential mediation effects, ranging from 3.81% to 13.57%.
Interpretation:
Higher NRS is associated with an increased risk of incident RA, particularly in individuals with high genetic susceptibility, with obesity partially mediating this association.
Limitations:
Conclusion:
NRS may serve as a tool for RA risk stratification and intervention.
Higher oxidative balance was associated with lower mortality, while greater systemic inflammation was linked to increased risk in a US cohort of patients with rheumatoid arthritis.
