Reply to: Letter “what defines an anatomic structure?” on “The Cuneus Vein: Initial Anatomical Description and Preservation Technique for Posterior Interhemispheric Approaches” - Summary - MDSpire

Response to the Inquiry: Defining Anatomical Structures in Relation to “The Cuneus Vein: An Initial Anatomical Overview and Technique for Preserving Posterior Interhemispheric Access”

  • By

  • Muhammet Enes Gurses

  • Abuzer Gungor

  • Uğur Türe

  • July 21, 2026

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Objective:

To discuss the anatomical and surgical implications of the cuneus vein in response to inquiries regarding its nomenclature and anatomical relationships.

Approach:
  • Anatomical Nomenclature: The authors clarify that the term 'cuneus vein' is a practical descriptor for a venous structure encountered intraoperatively, not a definitive addition to neuroanatomical terminology.
  • Asymmetry Observations: The authors acknowledge left-sided predominance of the cuneus vein but cannot determine its cause without further studies.
  • Clinical Series Evaluation: The study represents one of the largest clinical series evaluating the posterior interhemispheric approach, emphasizing the value of intraoperative observations.
  • Preoperative Detection Challenges: The authors agree that reliable radiological identification of the cuneus vein is challenging and emphasize the need for further studies.
Key Findings:
  • The cuneus vein is not anatomically related to the lingual gyrus, calcarine fissure, or parieto-occipital fissure.
  • Intraoperative findings provide the most direct anatomical information relevant to surgical conditions.
  • Only one patient experienced a vein injury, highlighting the need for standardized visual field assessments in future studies.
Interpretation:

The authors highlight the necessity for further anatomical and radiological studies to validate the existence and significance of the cuneus vein.

Limitations:
  • The study lacks large-scale cadaveric data due to practical challenges in specimen access.
  • Inadequate visualization of venous structures on preoperative imaging limits reliable identification.
  • Subclinical visual field damage cannot be ruled out without proper assessments.
Conclusion:

Further anatomical and radiological evaluation of the cuneus vein is necessary to enhance understanding and clinical utility.

Sources:

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