Updated Recommendations for Retinoblastoma Imaging: Insights from the European Retinoblastoma Imaging Collaboration and the European Retinoblastoma Group, 2025 Edition

By
Liesbeth Cardoen
Selma Sirin
Paolo Galluzzi
Marcus C. de Jong
Meriam Koob
Sophia Göricke
Christiaan M. de Bloeme
Maaike Moor
Isabelle Aerts
Alexandre Matet
Annette C. Moll
François Doz
Pim de Graaf
Hervé J. Brisse
August 6, 2025

European Radiology

Objective:

To present updated imaging guidelines for retinoblastoma and promote standardization of MRI protocols and reporting, which is crucial for consistent and accurate diagnosis.

Key Findings:

Ultrasound is essential for diagnosing retinoblastoma, especially when fundoscopy is limited.
MRI is crucial for assessing tumor extension and should be preferred over CT due to better sensitivity and lower radiation risk.
High-resolution contrast-enhanced MRI is necessary for accurate staging and identifying intracranial involvement.

Interpretation:

Advancements in imaging technology and understanding of retinoblastoma have led to refined guidelines that significantly enhance diagnostic accuracy and treatment planning.

Limitations:

General anesthesia is required for optimal MRI quality, which may not be feasible in all patients, potentially delaying diagnosis.
The 'feed-and-swaddle' technique may result in suboptimal image quality, impacting the accuracy of staging.

Conclusion:

The updated guidelines aim to standardize imaging practices for retinoblastoma, ultimately improving diagnosis and treatment outcomes for affected children.

Updated Recommendations for Retinoblastoma Imaging: Insights from the European Retinoblastoma Imaging Collaboration and the European Retinoblastoma Group, 2025 Edition

Objective:

Key Findings:

Interpretation:

Limitations:

Conclusion:

Original Source(s)

Practical guidelines on imaging of retinoblastoma: a 2025 update on behalf of the European Retinoblastoma Imaging Collaboration and the European Retinoblastoma Group

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