To investigate the association of cytokines IL-6 and IL-17 with premature coronary artery disease (pCAD), emphasizing the significance of gender-stratified analysis.
Key Findings:
Elevated levels of IL-6 and IL-17 were found in patients with pCAD compared to controls.
Cytokine levels correlated with traditional cardiovascular risk factors.
Gender-specific variations in cytokine levels were observed.
Interpretation:
IL-6 and IL-17 may serve as potential biomarkers for early detection and risk stratification of pCAD, highlighting the importance of inflammation in CAD progression and its implications for clinical practice.
Limitations:
Single-center study may limit generalizability; further multi-center studies are needed.
Retrospective design may introduce selection bias, affecting the reliability of findings.
Causality cannot be established due to cross-sectional nature, necessitating longitudinal studies.
Conclusion:
The study suggests that IL-6 and IL-17 could be valuable biomarkers for early-onset CAD, warranting further investigation for personalized treatment strategies and validation of findings.
