Artificial intelligence advancements for orthopaedic clinical reasoning: longitudinal assessment of newer models (ChatGPT-5, Grok-3, Gemini 2.5 Flash) compared to clinicians - Summary - MDSpire

Artificial intelligence advancements for orthopaedic clinical reasoning: longitudinal assessment of newer models (ChatGPT-5, Grok-3, Gemini 2.5 Flash) compared to clinicians

  • By

  • Suzen Agharia

  • Shayan Soroush

  • Daniel Ameen

  • Yushy Zhou

  • July 7, 2026

  • 0 min

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Objective:

To evaluate the alignment of newer LLMs with orthopaedic expert consensus and track changes in AI responses over time.

Approach:
  • Study Design: Re-tested 97 clinical cases using ChatGPT-5, Gemini 2.5 Flash, and Grok-3, comparing responses to pooled decisions from practicing clinicians.
  • AI Tools: Evaluated three updated LLMs: ChatGPT-5, Grok-3, and Gemini 2.5 Flash.
  • Clinical Cases: Sourced from OrthoBullets, covering various orthopaedic subspecialties with multiple-choice questions.
  • Outcome Measures: Primary outcome was the proportion of AI responses matching the most popular clinician response, with secondary analyses on response proximity and performance on controversial questions.
Key Findings:
  • The study provides a longitudinal evaluation of AI model performance in orthopaedic decision-making, tracking changes over time.
  • AI responses were compared against a benchmark of clinician consensus rather than absolute clinical accuracy.
  • The methodology allows for consistent evaluation of AI evolution over time.
Interpretation:

Limitations:
  • The study does not assess absolute clinical accuracy or guideline-derived ground truth.
  • Responses may still be regionally biased or dependent on training levels.
Conclusion:

Sources:

Original Source(s)

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