Objective:

To report a case of a patient with severe renal impairment due to anti-GBM disease and evaluate the impact of regular plasmapheresis on renal function, highlighting its significance in the context of existing literature.

Key Findings:

• The patient had an initial serum creatinine of 752 μmol/L and a high anti-GBM antibody titer of 92.54 RU/mL, alongside significant initial symptoms.
• After 25 rounds of plasmapheresis, the patient's renal function was successfully rescued and remained normal during a 5-year follow-up.
• Persistent plasmapheresis until the clearance of anti-GBM antibodies was crucial for the patient's recovery, suggesting a potential new approach for similar cases.

Interpretation:

Early and continuous plasmapheresis may improve outcomes in patients with severe anti-GBM disease, even with initially poor prognosis, indicating a need for reevaluation of treatment strategies.

Limitations:

• This is a single case study, limiting generalizability.
• The long-term effects of plasmapheresis in larger populations remain unclear, necessitating further research.

Conclusion:

The case suggests that early and persistent plasmapheresis can be beneficial for patients with severe anti-GBM disease, potentially influencing future treatment guidelines.