Timing and microbiological profile influence long-term outcomes after debridement, antibiotics, and implant retention (DAIR) in acute hip periprosthetic joint infection - Summary - MDSpire
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Timing and microbiological profile influence long-term outcomes after debridement, antibiotics, and implant retention (DAIR) in acute hip periprosthetic joint infection
To evaluate treatment failure-free survival at five years and identify clinical, microbiological, and procedural predictors of treatment failure in patients with acute hip PJI managed with DAIR.
Approach:
Outcome Assessment: Defined treatment failure as revision surgery, additional debridement, long-term suppressive antibiotic therapy, or PJI-related mortality.
Key Findings:
Mean follow-up was 7.1 years (SD 4.4), with a range of 0–20.3 years.
76.5% of patients developed infection following primary arthroplasty.
The interval between diagnosis and DAIR varied, reflecting real-world clinical practice.
Interpretation:
The study provides insights into long-term outcomes and factors influencing treatment failure in acute hip PJI managed with DAIR.
Limitations:
Retrospective design may introduce bias.
Inclusion of both primary and aseptic revision arthroplasty may affect outcome generalizability.
Variability in timing of DAIR procedures not standardized.
Conclusion:
Further data on mid- to long-term outcomes of DAIR for acute hip PJI is warranted to enhance understanding of treatment efficacy.
by Ernesto Muñoz-Mahamud, Juan Carlos Perdomo-Lizarraga, Andrés Combalia, Alfonso Alías, Adrià Serra, Jenaro Ángel Fernández-Valencia, Miguel Ángel Verdejo, Álex Soriano
