Glial Fibrillary Acidic Protein and Neurofilament Light Reference Intervals in Healthy Individuals - Summary - MDSpire

Glial Fibrillary Acidic Protein and Neurofilament Light Reference Intervals in Healthy Individuals

  • By

  • Rebecca Z. Rousset

  • Madison I. J. Honey

  • Anouk den Braber

  • Wiesje M. van der Flier

  • Henne Holstege

  • Linda Lorenz

  • Mark H. J. Wessels

  • Joep Killestein

  • Martijn Huisman

  • Almar Kok

  • Marian Beekman

  • P. Eline Slagboom

  • Lannie Ligthart

  • Eco de Geus

  • Inge M. W. Verberk

  • Lisa Vermunt

  • Charlotte E. Teunissen

  • May 14, 2026

  • 0 min

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Objective:

To determine the association of age, sex, kidney function, and BMI with plasma GFAP and NfL concentrations in a healthy population, highlighting their clinical significance.

Key Findings:
  • GFAP and NfL concentrations increase with age, with specific data points indicating the magnitude of change.
  • Sex, kidney function, and BMI influence GFAP and NfL levels, with quantifiable effects.
  • Established reference intervals provide a framework for interpreting biomarker concentrations in clinical settings, enhancing diagnostic accuracy.
Interpretation:

The study provides comprehensive reference intervals for GFAP and NfL, accounting for biological modifiers, thereby enhancing clinical interpretation and potential diagnostic applications.

Limitations:
  • The study is cross-sectional, limiting causal inferences and potentially introducing selection bias.
  • Potential confounding factors may not be fully accounted for, including lifestyle and environmental influences.
Conclusion:

The findings establish important reference intervals for GFAP and NfL, which can aid in the assessment of neurological conditions, aligning with existing literature on biomarker utility.

Original Source(s)

Glial Fibrillary Acidic Protein and Neurofilament Light Reference Intervals in Healthy Individuals

  • by Rebecca Z. Rousset, Madison I. J. Honey, Anouk den Braber, Wiesje M. van der Flier, Henne Holstege, Linda Lorenz, Mark H. J. Wessels, Joep Killestein, Martijn Huisman, Almar Kok, Marian Beekman, P. Eline Slagboom, Lannie Ligthart, Eco de Geus, Inge M. W. Verberk, Lisa Vermunt, Charlotte E. Teunissen

  • May 14, 2026

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