To explore the links between gut microbiota and risk of HIV acquisition in HIV-negative men who have sex with men (MSM).
Key Findings:
High-risk participants had >2 male partners and engaged mostly in receptive anal intercourse.
High-risk group exhibited higher Shannon index and lower Simpson index, indicating increased gut microbiota diversity.
Beta diversity analysis showed significant differences between high-risk and low-risk groups (F = 2.0245, P = .0369).
Linear discriminant analysis revealed Barnesiella was significantly increased in the low-risk group, while Roseburia was higher in the high-risk group.
Interpretation:
The study suggests that gut dysbiosis is associated with an increased risk of HIV acquisition in MSM, indicating potential for developing gut microbiota-targeted HIV prevention strategies.
Limitations:
Cross-sectional design limits causal inference.
Sample size and geographic limitation may affect generalizability.
Potential biases in self-reported sexual behavior data.
Conclusion:
Gut microbiota composition may serve as a potential target for HIV prevention strategies among MSM.
Study found species-specific differences in biofilm -forming capacity and antimicrobial susceptibility among supragingival bacterial isolates from patients with active dental caries.
