To evaluate the association between tumor gene mutation profiles, tumor mutational burden (TMB), and the occurrence of PD-1 inhibitor-induced hypophysitis.
Key Findings:
The hypophysitis group had a higher overall tumor mutational burden (6.02 vs. 5.19 mut/Mb, P = 0.002).
Significantly higher mutation rates in genes BABAM1 (18.2% vs. 0%, P = 0.014), KDM5C (18.2% vs. 0%, P = 0.014), CDH4 (19.2% vs. 1.8%, P = 0.018), and TAL1 (19.2% vs. 1.8%, P = 0.018) were found in the hypophysitis group.
PAXIP1 mutations were more common in the non-hypophysitis group (19.6% vs. 0%, P = 0.037), suggesting a potential protective role.
Interpretation:
Remove this section.
Limitations:
The study is retrospective and conducted at a single center, which may limit generalizability.
The sample size is relatively small, particularly in the hypophysitis group.
Conclusion:
Revise to state only the findings without unsupported implications.
