Association between circulating biomarkers of one-carbon metabolism and glymphatic system function in cognitive decline of Alzheimer’s disease - Summary - MDSpire
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Association between circulating biomarkers of one-carbon metabolism and glymphatic system function in cognitive decline of Alzheimer’s disease
To investigate the association between one-carbon metabolism (OCM) biomarkers and glymphatic function in Alzheimer's disease (AD) and explore their combined effects on cognition, highlighting the significance of these relationships in understanding AD pathology.
Key Findings:
Serum folate levels and DTI-ALPS index significantly differed between normal cognition and AD groups (p = 0.020 and p < 0.001, respectively).
Folate levels were positively correlated with DTI-ALPS index in AD patients (r = 0.212, pFDR = 0.032).
The low-risk group (high folate and high DTI-ALPS index) outperformed the high-risk group in cognitive performance measures, including memory (p = 0.001) and processing speed (p = 0.005).
Interpretation:
Lower serum folate levels and reduced glymphatic function are associated with poorer cognitive performance in AD, suggesting a potential link between metabolic status and glymphatic function, which may have implications for treatment strategies.
Limitations:
The study is cross-sectional and does not establish causality.
Longitudinal studies are needed to confirm findings and explore potential therapeutic interventions.
Conclusion:
The findings indicate that impaired one-carbon metabolism and glymphatic function may contribute to cognitive decline in AD, warranting further investigation to explore their roles in AD pathology.
