To assess the associations between uric acid to lymphocyte ratio (ULR) and poor functional prognosis and all-cause mortality in patients with acute ischemic stroke (AIS), highlighting its significance in clinical outcomes.
Key Findings:
Patients in the highest ULR quartile had higher mRS scores of 2–6 (OR, 1.33; 95% CI, 1.15–1.53) and 3–6 (OR, 1.35; 95% CI, 1.16–1.57) at 3 months, based on a total of 8,241 patients.
The highest ULR quartile was associated with increased risk of all-cause mortality at 3 months (HR, 1.97; 95% CI, 1.22–3.18), with similar results observed at the 1-year follow-up.
Interpretation:
Elevated ULR is linked to poorer functional outcomes and increased all-cause mortality in AIS patients.
Limitations:
Potential unmeasured confounders may affect the validity of the findings.
Selection bias could limit the generalizability of the results.
Residual confounding may still exist despite adjustments.
Findings may not be applicable to populations outside the study sample.
Conclusion:
Elevated ULR increases risks of poorer functional outcomes and all-cause mortality in AIS patients.
