Association of metabolic syndrome with ruptured status of intracranial aneurysms in a definitively treated cohort: a retrospective cohort analysis - Summary - MDSpire
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Association of metabolic syndrome with ruptured status of intracranial aneurysms in a definitively treated cohort: a retrospective cohort analysis
To examine the association between metabolic syndrome (MetS), its burden, and individual components with ruptured status in patients with intracranial aneurysms undergoing definitive treatment.
Key Findings:
MetS was more prevalent in the ruptured group (59.9%) compared to the unruptured group (40.1%).
Binary MetS was independently associated with ruptured status (adjusted OR 1.83, 95% CI 1.31–2.54).
Higher MetS scores showed a graded association with ruptured status.
Elevated glucose (adjusted OR 2.56), reduced high-density lipoprotein cholesterol (adjusted OR 2.35), and elevated blood pressure (adjusted OR 1.71) had the strongest associations with ruptured status.
The component-based model had the highest AUC (0.711), indicating moderate discrimination.
Interpretation:
The findings suggest an association between MetS and ruptured intracranial aneurysm status, with specific components showing stronger associations.
Limitations:
The study is retrospective and cannot establish causality.
