Opioid Use and Pain Resolution for Acute Pain Among Opioid-Naive Patients - Summary - MDSpire

Opioid Use and Pain Resolution for Acute Pain Among Opioid-Naive Patients

  • By

  • Molly Moore Jeffery

  • Fernanda Bellolio

  • Nancy Chang

  • Summer Allen

  • Marie-Carmelle Elie-Turenne

  • W. Jonathan Fillmore

  • Gregg H. Gilbert

  • Rebekah Heckmann

  • Patricia Koussis

  • Christine Lee

  • Heather Lipkind

  • Tamra E. Meyer

  • Teryl K. Nuckols

  • Jessica D. Ritchie

  • Michael A. Pacanowski

  • David B. Page

  • Mat Soukup

  • Stephen Tamang

  • Sam Torbati

  • Doug Wallace

  • Lauren Walter

  • Yueqin Zhao

  • Nilay D. Shah

  • Mitra Ahadpour

  • Joseph S. Ross

  • July 7, 2026

  • 0 min

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Objective:

To collect patterns of treatment use and pain trajectories among opioid-naive patients prescribed opioids for acute pain across various clinical settings.

Approach:
  • Study Design: Prospective cohort study involving opioid-naive adults aged 18 and older, recruited from multiple clinical settings.
  • Data Collection: Patients completed digital questionnaires on demographics, clinical history, and pain management outcomes.
  • Outcome Measures: Primary outcomes included time to pain resolution and treatment patterns; secondary outcomes included pain relief, opioid-related adverse effects, and opioid discontinuation.
Key Findings:
  • No single class of medication was found superior for managing acute pain across various conditions.
  • Wide variation in opioid prescribing practices was observed among similar patients.
  • Underrepresented populations were prioritized for enrollment to address gaps in existing evidence.
Interpretation:

Limitations:
  • The study may not generalize to all acute pain populations due to specific inclusion criteria.
  • Self-reported data may introduce bias in pain assessment and treatment effectiveness.
Conclusion:

The study provides insights into opioid prescribing and pain management in opioid-naive patients.

Sources:

Original Source(s)

Opioid Use and Pain Resolution for Acute Pain Among Opioid-Naive Patients

  • by Molly Moore Jeffery, Fernanda Bellolio, Nancy Chang, Summer Allen, Marie-Carmelle Elie-Turenne, W. Jonathan Fillmore, Gregg H. Gilbert, Rebekah Heckmann, Patricia Koussis, Christine Lee, Heather Lipkind, Tamra E. Meyer, Teryl K. Nuckols, Jessica D. Ritchie, Michael A. Pacanowski, David B. Page, Mat Soukup, Stephen Tamang, Sam Torbati, Doug Wallace, Lauren Walter, Yueqin Zhao, Nilay D. Shah, Mitra Ahadpour, Joseph S. Ross

  • July 7, 2026

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