Objective:

To compare clinical, epidemiological, inflammatory, and laboratory characteristics between patients with right- and left-sided colorectal cancer, considering the presence of cachexia.

Approach:

• Study Design: Retrospective observational cohort study including 69 patients who underwent surgical treatment for colorectal cancer at the University Hospital of the University of Sao Paulo between 2012 and 2018.
• Patient Classification: Patients were classified as cachectic (CC; n = 40) or non-cachectic (WSC; n = 29) based on weight loss criteria.
• Data Collection: Clinical, epidemiological, inflammatory, nutritional, and laboratory variables were compared according to cachexia status, primary tumor location, and survival status.

Key Findings:

• Cachectic patients had significantly lower BMI, hemoglobin, and albumin levels, and higher CRP concentrations, CRP/albumin ratio, GPS, and mGPS values compared to non-cachectic patients.
• Cachexia was more frequent among patients with right-sided tumors, although this difference was not statistically significant.
• Patients who died during follow-up were significantly older than survivors.

Interpretation:

Limitations:

• Small sample size of 69 patients may limit the generalizability of findings.
• Retrospective design may introduce biases in data collection and analysis.

Conclusion:

Further multicenter studies with larger samples and complete longitudinal follow-up are needed to clarify the prognostic implications of these findings.