Clinical efficacy and safety of different video-assisted thoracoscopic surgery approaches for bullous lung resection: a systematic review and meta-analysis - Summary - MDSpire

Clinical efficacy and safety of different video-assisted thoracoscopic surgery approaches for bullous lung resection: a systematic review and meta-analysis

  • By

  • Ting Gao

  • Xiaopeng He

  • Peiwen Zhao

  • May 29, 2026

  • 0 min

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Objective:

To evaluate the perioperative safety and comparative efficacy of single-port (conventional or modified) versus multi-port video-assisted thoracoscopic surgery (VATS) for bullous lung resection in patients with primary spontaneous pneumothorax.

Key Findings:
  • Thirteen cohort studies (1,151 patients) were included. Single-port VATS resulted in a significantly reduced hospital stay (MD = 0.246 days; 95% CI, 0.075–0.416).
  • Postoperative pain was significantly lower in single-port VATS (MD = 1.100; 95% CI, 0.528–1.671).
  • Incidence of chest wall paresthesia was lower in single-port VATS (risk ratio = 0.580; 95% CI, 0.432–0.779).
  • No significant differences were found in operative time, chest tube duration, stapler use, complications, or recurrence rates.
Interpretation:

Single-port VATS is associated with accelerated recovery, reduced postoperative pain, and lower neurological sequelae compared to multi-port VATS, without increasing operative time or complication rates. Further randomized trials are needed to establish superiority.

Limitations:
  • Majority of studies were small-scale, single-center retrospective cohorts, limiting statistical power.
  • Variability in modified single-port protocols and pleurodesis techniques.
  • Many studies lacked critical intraoperative data, such as stapler utilization.
Conclusion:

Single-port VATS represents a safe and feasible alternative for bullous lung resection, although further randomized trials are needed to establish superiority.

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