Safety outcomes of mucomuscular closure versus conventional clip closure in ESD of large (> 15 mm) nonpedunculated colorectal polyps (LNPCPs) - Summary - MDSpire
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Safety outcomes of mucomuscular closure versus conventional clip closure in ESD of large (> 15 mm) nonpedunculated colorectal polyps (LNPCPs)
To evaluate the feasibility and efficacy of a novel closure technique in preventing post-endoscopic submucosal dissection electrocoagulation syndrome (PEECS) compared to conventional methods.
Key Findings:
The incidence of PEECS was significantly lower in the mucomuscular closure group (2.5%) compared to the conventional closure group (15.0%, P < 0.001).
No severe adverse events (SAEs) occurred in the mucomuscular closure group.
In the conventional closure group, two patients experienced delayed perforation and two had delayed bleeding.
No TTSC-related perforation occurred during defect closure.
Interpretation:
Mucomuscular closure using through-the-scope clips effectively reduces the incidence of PEECS and other postoperative complications following C-ESD.
Limitations:
The study was conducted at a single center, which may limit the generalizability of the findings.
The sample size for the mucomuscular closure group may not be large enough to fully assess long-term outcomes and potential biases.
Conclusion:
Mucomuscular closure with TTSC is a promising technique for preventing complications associated with C-ESD, warranting further investigation in larger, multi-center studies.
