Incidence and Survival of Gastro-Entero-Pancreatic Neuroendocrine Neoplasms in the Contemporary Era

To examine the incidence and survival of patients diagnosed with gastro-entero-pancreatic neuroendocrine tumors (GEP-NENs) over the past 2 decades.

GEP-NENs have become one of the most prevalent gastrointestinal malignant neoplasms.
There has been a significant increase in the incidence of GEP-NENs since the early 2000s.

The study is limited to the Ontario population and may not reflect trends in other jurisdictions.
Data is retrospective and may be subject to biases inherent in administrative health datasets.

The study provides updated epidemiologic data on GEP-NENs, highlighting trends in incidence and survival over the past two decades.

Jama Network Open

by Julie Hallet, Léamarie Meloche-Dumas, Carlotta Sarzo, Colin Court, Jessica Armah, Anna Ding, Wing C. Chan, Simron Singh
June 3, 2026