Human NKT10 cells are enriched in cord-derived invariant natural killer T cells and mediate immune-regulation in a xenogeneic graft-versus-host disease model - Summary - MDSpire

Human NKT10 cells are enriched in cord-derived invariant natural killer T cells and mediate immune-regulation in a xenogeneic graft-versus-host disease model

  • By

  • Abel Trujillo-Ocampo

  • Pamella Borges

  • Maison Grefe

  • Martiela Vaz de Freitas

  • Sung-Eun Lee

  • Yuan Qi

  • Jelita Clinton

  • Dan Li

  • Hong He

  • Ling Yu

  • Arnau Peris-Cuesta

  • Erik A. Ehli

  • Qing Ma

  • Xiaoping Su

  • Dinler Amaral Antunes

  • Gheath Al-Atrash

  • Jeffrey J. Molldrem

  • Elizabeth J. Shpall

  • Jin S. Im

  • June 10, 2026

  • 0 min

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Objective:

To characterize human NKT10 cells from cord-derived iNKT cells and investigate their role in immune regulation in allogeneic stem cell transplantation.

Approach:
    Key Findings:
    • Cord-derived iNKT cells contained a high frequency of CD4+CD25+CD161lowFoxP3+ iNKT cells.
    • These cells showed Th2/Th10-biased cytokine production upon antigenic stimulation.
    • Single-cell RNA sequencing confirmed the presence of an NKT10-like subset enriched with immunoregulatory pathways.
    • Cord-derived iNKT cells suppressed alloreactive T cell proliferation in vitro.
    • In vivo, these cells ameliorated xenogeneic graft-versus-host disease in NSG mice.
    Interpretation:

    Limitations:
    • The study primarily focuses on cord-derived iNKT cells, limiting generalizability to other sources.
    • Further clinical studies are needed to validate the findings regarding NKT10 cells.
    Conclusion:

    NKT10 cells from cord-derived iNKT cells exhibit significant immunoregulatory properties.

Original Source(s)

Human NKT10 cells are enriched in cord-derived invariant natural killer T cells and mediate immune-regulation in a xenogeneic graft-versus-host disease model

  • by Abel Trujillo-Ocampo, Pamella Borges, Maison Grefe, Martiela Vaz de Freitas, Sung-Eun Lee, Yuan Qi, Jelita Clinton, Dan Li, Hong He, Ling Yu, Arnau Peris-Cuesta, Erik A. Ehli, Qing Ma, Xiaoping Su, Dinler Amaral Antunes, Gheath Al-Atrash, Jeffrey J. Molldrem, Elizabeth J. Shpall, Jin S. Im

  • June 10, 2026

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