Objective:

To elucidate current trends and research hotspots in the field of metabolic syndrome (MetS) and metabolic dysfunction-associated fatty liver disease (MAFLD), thereby offering fresh perspectives to guide future investigations.

Key Findings:

• A total of 9,821 publications were analyzed from 120 countries/regions.
• The United States led with 2,426 publications, followed by China and Italy.
• The University of California System was the most prolific research institution.
• The World Journal of Gastroenterology was the leading journal in publication volume.
• Keyword trends evolved from 'insulin resistance' and 'morbid obesity' to 'mitochondrial dysfunction' and 'gut microbiota'.
• Targher Giovanni emerged as the most influential contributor, followed by Younossi Zobair M. and Yilmaz Yusuf.

Interpretation:

The study indicates a significant increase in research output and a shift in focus towards mechanism-based diagnosis and early intervention strategies in MetS and MAFLD, highlighting the need for innovative approaches in clinical practice.

Limitations:

• The study is limited to publications in English, which may exclude relevant studies in other languages.
• Only articles and review articles were included, potentially excluding important data from other formats.

Conclusion:

The bibliometric analysis provides insights into the evolving landscape of MetS and MAFLD research, highlighting emerging trends and the need for further investigation to enhance understanding and management of these conditions.