Objective:

To present Phase 1 data on a novel interventional approach for locally advanced pancreatic cancer.

Approach:

• Study Design: The study targets patients with tumors encasing major vessels, making them unresectable despite induction chemotherapy.
• Intervention: Combines parallel photodynamic therapy with intravascular laser activation via a balloon catheter to destroy perivascular tumor tissue.

Key Findings:

• Successfully converted previously inoperable cases into candidates for Whipple procedures.
• Potentially increased five-year overall survival rates from 10-15% to 40-50%.

Interpretation:

Conclusion:

The study presents a significant advancement in the treatment of locally advanced pancreatic cancer.