Refractive outcomes following anti-VEGF, vitrectomy, cryotherapy, and laser photocoagulation for retinopathy of prematurity: a systematic review and meta-analysis - Summary - MDSpire
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Refractive outcomes following anti-VEGF, vitrectomy, cryotherapy, and laser photocoagulation for retinopathy of prematurity: a systematic review and meta-analysis
To evaluate and compare long-term refractive outcomes in ROP survivors treated with anti-VEGF, laser photocoagulation, cryotherapy, and vitrectomy.
Key Findings:
Anti-VEGF treatment had the least myopic pooled mean SE at -1.9 D.
High myopia prevalence was 21.3% after anti-VEGF, compared to 42.6% after laser and 55.4%-58.6% after cryotherapy or vitrectomy.
Anti-VEGF significantly reduced the risk of high myopia compared to laser (RR = 0.39; 95% CI: 0.25–0.61).
Interpretation:
Anti-VEGF treatment is associated with better long-term refractive outcomes in ROP survivors compared to traditional methods like cryotherapy and vitrectomy.
Limitations:
Moderate to high heterogeneity in results (I2 = 52%–78%).
Potential biases in included studies and variability in reporting refractive outcomes.
Conclusion:
Anti-VEGF is the most favorable treatment for minimizing myopic burden in ROP, suggesting the need for consideration of long-term refractive outcomes in treatment planning.
FOXC1 duplications were the second most common monogenic finding among genetically solved juvenile open-angle glaucoma cases in one registry, supporting the use of copy-number variant analysis in early-onset glaucoma testing.
