Association of blood urea nitrogen to albumin ratio with cerebral small vessel disease and its ischemic imaging markers: a cross-sectional study - Summary - MDSpire
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Association of blood urea nitrogen to albumin ratio with cerebral small vessel disease and its ischemic imaging markers: a cross-sectional study
To assess the association between blood urea nitrogen to albumin ratio (BAR) and cerebral small vessel disease (CSVD) and its ischemic neuroimaging markers.
Key Findings:
BAR was positively associated with CSVD (OR: 1.77, p < 0.001), WMH (OR: 1.55, p < 0.001), and EPVS (OR: 2.09, p < 0.001).
No significant association was found between BAR and lacunes (OR: 1.12, p = 0.302).
Higher quantiles of BAR were linked to increased risk of CSVD (OR: 2.40 for middle, 4.25 for highest quantile).
The association between BAR and CSVD/WMH was linear and dose-responsive, while EPVS showed a nonlinear relationship.
ROC analysis indicated BAR's association with CSVD (AUC: 0.701) and optimal model performance (AUC: 0.914).
Interpretation:
BAR may serve as a novel and cost-effective biomarker for identifying CSVD and its ischemic imaging markers, suggesting its potential utility in risk stratification and primary care screening.
Limitations:
Cross-sectional design limits causal inference.
Study population may not be representative of the general population.
Conclusion:
BAR is independently associated with CSVD and its ischemic imaging markers, warranting further investigation for its role in clinical practice.
