Case Report: A literature review of the medical complications arising from etomidate-laced vapes and two case studies of hypokalemia associated with etomidate use - Summary - MDSpire

Case Report: A literature review of the medical complications arising from etomidate-laced vapes and two case studies of hypokalemia associated with etomidate use

  • By

  • Tian Ling Low

  • Christopher Cheng Soon Cheok

  • Melvyn Weibin Zhang

  • June 17, 2026

  • 0 min

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Objective:

To report cases of asymptomatic hypokalemia in patients using etomidate-laced vaporizers and to highlight the associated medical issues.

Approach:
    Key Findings:
    • Both patients exhibited asymptomatic hypokalemia (serum potassium levels of 2.9 mmol/L and 3.3 mmol/L).
    • Both patients presented with diffuse and palmer crease hyperpigmentation, indicative of potential adrenal dysfunction.
    Interpretation:

    The findings suggest that asymptomatic hypokalemia may be a common but overlooked complication in patients misusing etomidate-laced vaporizers, necessitating early screening.

    Limitations:
    • The study is based on a small sample size of two case reports.
    • The findings may not be generalizable to all populations due to regional differences in etomidate use.
    Conclusion:

    Early screening for hypokalemia in patients using etomidate-laced vaporizers is important to prevent severe adrenal complications.

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