Non-invasive radiogenomic mapping of the SMARCAL1-driven ferroptotic niche is associated with longitudinal MRD-negative surveillance in early-stage NSCLC - Summary - MDSpire
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Non-invasive radiogenomic mapping of the SMARCAL1-driven ferroptotic niche is associated with longitudinal MRD-negative surveillance in early-stage NSCLC
To investigate whether pre-operative radiomic features can non-invasively capture the spatial organization of a ferroptosis-enriched, immune-active tumor microenvironment associated with sustained post-operative MRD negativity in early-stage NSCLC.
Key Findings:
High Rad-Score patients had longer metastasis-free survival (MFS) with HR = 0.32, P < 0.001.
Rad-Score remained independent after adjustment for 13 clinical covariates (adjusted HR = 0.66, P = 0.022).
High Rad-Score tumors exhibited elevated tumor mutational burden (TMB) and enriched CD8+ T cells and M1 macrophages.
SMARCAL1 knockout conferred resistance to ferroptosis and attenuated CXCR3+ CD8+ T cell transmigration.
Interpretation:
Remove unsupported conclusions and interpretations.
Limitations:
Study conducted at a single center, which may limit generalizability.
Requires prospective validation.
Conclusion:
Revise to eliminate unsupported claims and reflect only the findings presented.
