Inflammatory bowel diseases in the elderly population: epidemiology, long-term disease course, surgery rates, and biological use—data from the Veszprem county cohort between 1977 and 2020 - Summary - MDSpire
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Inflammatory bowel diseases in the elderly population: epidemiology, long-term disease course, surgery rates, and biological use—data from the Veszprem county cohort between 1977 and 2020
To analyze incidence, disease course, surgery rates, and specific therapeutic strategies (e.g., medication types) of elderly-onset (EO) inflammatory bowel diseases (IBD) in a population-based cohort.
Key Findings:
6.1% of Crohn's disease (CD) and 13.4% of ulcerative colitis (UC) patients were elderly-onset.
Biological therapy exposure was significantly lower in EO CD compared to adult-onset (AO) CD (pLogRank = 0.003).
Early surgery rates were higher in EO CD patients (27.6%) compared to AO (15.6%; P < .001).
No significant difference in overall surgery rates between EO and AO cohorts for CD (pLogRank = 0.838) and UC (pLogRank = 0.435).
Disease phenotype progression was lower in EO patients for both CD (pLogRank = 0.015) and UC (pLogRank = 0.022).
Interpretation:
Elderly-onset IBD represents an increasing proportion of IBD patients, with distinct disease characteristics and treatment responses compared to younger patients, highlighting the need for tailored management approaches.
Limitations:
Limited data on long-term outcomes for elderly-onset IBD, which may affect treatment decisions.
Potential biases in patient selection and treatment exposure could influence the findings.
Conclusion:
Elderly-onset IBD patients show higher early surgery rates in CD but similar overall surgery rates compared to younger cohorts, indicating a need for tailored management strategies, such as individualized treatment plans.
by Dorottya Angyal, Lorant Gonczi, Fruzsina Balogh, Panu Wetwittayakhlang, Petra A Golovics, Tunde Pandur, Gyula David, Zsuzsanna Erdelyi, Istvan Szita, Akos Ilias, Laszlo Lakatos, Peter L Lakatos
